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Neanderthal genome tells a human story

first_imgA preliminary draft of the genome of the Neanderthal, our closest evolutionary relative, reveals in exquisite detail how this long-extinct member of the Homo genus relates to modern humans.The work for the project was carried out in two phases. In the first phase, scientists at the Max Planck Institute in Leipzig, Germany extracted a genome’s worth of DNA from bonesapproximately 40,000 years old, taken from a cave in Croatia. In the second phase, an international consortium analyzed the data to study how Neanderthals are related genetically to modern humans. A key analysis — led by Harvard Medical School (HMS) associate professor of genetics David Reich — revealed that Neanderthals interbred with ancestors of modern Europeans and Asians, but not Africans.“Europeans and East Asians today bear a closer relationship to Neanderthals than do Africans,” says Reich. “One to four percent of the genomes of non-Africans trace their ancestry to Neanderthals. Europeans and Asians both have this signal, indicating that the gene flow occurred at least 45,000 years ago, before these two populations’ ancestors separated.”These findings are published in the May 6 issue of Science.From ancient ancestors . . .Neanderthals, who became extinct roughly 30,000 years ago for unknown reasons, and who diverged from modern human ancestors 270,000-440,000 years ago, have long been a subject of intense speculation. They are the closest population in the fossil record to anatomically modern humans, yet they are clearly distinct in terms of their physical structure.Neanderthals had bigger faces than we do, with more barrel-shaped chests and shorter limbs, and were most likely better adapted to colder climates. Their brains, despite being a bit longer with possibly smaller temporal lobes, were generally the same size as ours.The fossil record shows that modern humans and Neanderthals overlapped geographically for tens of thousands of years in Europe and Asia. From this evidence springs the obvious question: Did the two species intermingle and pool their genes?. . . to distant cousinsFor more than a decade, a group of researchers led by Svante Pääbo at the Max Planck Institute has been attempting to obtain sequences from the Neanderthal genome using pill-sized samples of powder extracted from bone fragments. This type of work is often thwarted by sample contamination (the majority of DNA extracted in such experiments turns out to come from microbes, or from a hapless laboratory technician). However, the researchers increased the purity of their samples by taking advantage of technological advances that could both detect and filter out contamination of the genetic material.The result was a reconstruction of more than 4 billion base pairs of DNA assembled from a variety of cells. This total represents roughly 60 percent of the Neanderthal genome.An international team of geneticists led by David Reich then studied how Neanderthals and modern humans are related by comparing this new genomic data to five present-day humans from far-flung regions of the world. Reich and his colleagues discovered that roughly one to four percent of the genomes of all non-African modern humans are directly descended from the Neanderthal. What’s more, these modern groups all appear equally related to their “distant” cousins.One explanation for this uniform genetic distribution is that interbreeding occurred at the gateway of the migration of modern humans out of Africa in the upper Paleolithic period, roughly 45,000 years ago. From points in Northern Africa—that is, modern-day countries such as Libya and Egypt—modern humans dispersed throughout Europe and East Asia.“That’s not the only explanation, but it’s the most likely one,” says Reich.As far as the researchers can tell, this small percentage of inherited DNA is random. There is no evidence that it is associated with specific traits.According to Harvard University professor of human evolutionary biology Daniel Lieberman, who was not involved with the study, we shouldn’t be terribly surprised at this evidence of interbreeding. “I do not think this in any way lessens the evidence that Neanderthals and modern humans were indeed separate species. Closely related species often do interbreed to a limited extent.”Clearly, the data is a treasure trove for future study. “There is a tremendous amount of yet untapped information in this genome,” says Reich, “and we’re going to bespending many more decades getting closer to what it all means.”last_img read more

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Ultra fear

first_imgAn ultra race distance is basically defined as any distance longer than a marathon. However as most of you probably already know, ultra distances generally start at 50k or 31.2 miles. Then from there you can migrate upward to 40 mile, 50 mile, 100k, 100 mile, 24 hour and 48 hour race distances as the general norm.I’ve been asked so many times how does one run that far. This usually comes from other runners who have already run a marathon and just can’t seem to comprehend the ultra distance. In reality a 50k is only five miles further than a marathon and a lot of runners progress up from half marathons to the marathon which is exponentially a much greater jump in distance. (50% vs 16%) Even using this logic, the mental component to running an ultra distance is as much a road block as the physical it seems.The word “ultra” has that impression that one will be undertaking something truly epic, scary and painful. This is usually not the case, in fact if you prepare properly and have already run at least one marathon within the last year then I see no reason why someone can not make the 16% jump in distance to a 50k ultra.The greatest difference between a marathon and an ultra is that most marathons are run on paved surfaces (more painful but faster pace) and most ultras are run on soft surfaces like trails (less painful but slower pace). Time on your feet is the main difference between the two but ultra running time is usually spent on a more forgiving surface. I have raced the 50k distance in times ranging from three hours to five hours. These times are primarily dictated by the terrain and sometimes weather. When choosing your first 50k look for a race that does not have an extremely technical surface and mountainous terrain and you’ll see the jump in distance is not one to be feared.  You will need to add some time to your long runs and try to mimic the course terrain as best as possible. Learning how to run slower so you can go longer does take patience and practice. Look at past times for the 50k you have chosen and this should give you a gage of how far to take your long runs. Just like for the marathon you do not need to complete the full distance in your training but try to get close to 85% covered with at least two long runs around three to five weeks out from your race. 1 2last_img read more

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7 ways financial institutions can turn their offices into a recruiting tool

first_img continue reading » With the unemployment rate below 4%, it’s a tough hiring market right now. Banks and credit unions trolling for top talent to fill increasingly important data analytics, customer experience, and digital transformation positions need every edge they can get.Think about it: we spend most of our lives working. A boring office space doesn’t help. Do you or your employees consider your place of employment a fun place to work? While the workspace may not trump the comp package, a financial institution’s office layout, design and overall vibe definitely can help attract and hold top talent.If your workspace is coming up short, consider introducing some of these design elements that can bring people together to remain engaged and energized, without compromising privacy. ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrlast_img read more

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Meghan snatches victory with final round 65

first_img23 Apr 2015 Meghan snatches victory with final round 65 England international Meghan MacLaren shot a final round of 65 to come from six shots back and snatch her seventh victory on the US women’s college circuit. She had five birdies – four of them in a row – and an eagle in a bogey-free round at the C-USA Women’s Golf Championships in Fort Myers, Florida. Crucially, though, she pulled off a great up-and-down for par on the 16th and holed a tricky six-footer for another par on 18 to seal the one-shot victory over Samantha Gotcher. MacLaren, from Wellingborough in Northamptonshire, commented: “I managed to make an up and down on 16 for par which I would probably only make one out of 20 times – and it was a better feeling than any of the birdies! I didn’t know how important it would be because Samantha finished with two birdies in a row. “The18th hadn’t been my favourite hole and my first putt just refused to stop, so I was left with a side-hill six-footer for par. I knew it was to win, so seeing it sneak in the right side was one of the happiest moments I’ve ever had on the course!” The 20-year-old student from Florida International has been confident with her putting all week and it paid off with three consecutive birdies from the seventh. She made it four in a row when she chipped in for another birdie on 10. “It just felt like one of those days where everything was going to go right, but I actually missed the shortest chance I had on 11 for birdie, and things slowed down a bit. I just made regulation pars and then hit two great shots to give myself a 12ft eagle putt on 15, which I missed, but made birdie to get to seven-under.” Her 65 was the second-lowest round in her university’s history and she set a personal and a college record for a 54-hole total of 206. MacLaren, a member of the England Golf women’s squad, staged a similar charge to win the British women’s stroke play championship last summer. In that event she shared 16th place at the halfway stage and played the final 36 holes in nine-under to win by a shot. Image © Leaderboard Photographylast_img read more

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SA software tracks umpires

first_img28 July 2005The International Cricket Council (ICC) is using South African-developed software to monitor decisions made by international umpires.According to the Council, more than 3 500 umpiring decisions are made in test matches and one-day international (ODI) series each year. About 90% on average are correct.However, since on-field decisions are based on an umpire’s judgement, controversial calls will feature in all matches.In an effort to ensure that umpiring standards are upheld and that decisions during a match are consistent and accurate, the ICC makes use of a sophisticated video-based umpire assessment system known as Umpirestat, devised by SA’s Council for Scientific and Industrial Research (CSIR).All international cricket matches in which elite umpires are involved are recorded on video tape, which is subsequently sent to the ICC along with the referee and captains’ reports on the umpires’ performance. Umpirestat then permits a frame-by-frame analysis of all the calls made during a matchAccording to Dr Tony Kirkbride, manager of the CSIR’s Sports Technology Centre, an analyst extracts the video clips of all decisions, including any controversial calls, made by the umpires. These decisions can then be reviewed by the assessor or individual umpire.The ICC reviews the video clips to determine the accuracy of the umpires’ decisions and provides them with a comprehensive report.These assessments provide the basis on which the ICC’s Umpires and Referees Manager is able to discuss any areas of concern with the umpires directly and provide feedback underpinned with video footage.The CSIR developed the software from Crickstat, a programme its devised to analyse cricket matches.The ICC currently assesses umpires on five areas: correct decisions, coping with pressure, player management, communication, and application of regulations.Umpirestat underpins this process by providing accurate and objective data on decisions.Source: Council for Scientific and Industrial Research Want to use this article in your publication or on your website?See: Using SAinfo materiallast_img read more

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Rewards for info on rhino poachers

first_img13 December 2012 South African National Parks (SANParks) is offering a cash reward of R100 000 to anyone who can provide information leading to the arrest of poachers and a further R1-million for a successful conviction of a poaching syndicate mastermind. “We are also happy to announce our partnership with South Africa’s Crime Line, a ground-breaking initiative that allows members of the public to make anonymous SMS tip-offs on suspected crimes at any time of the day,” SANParks chief executive officer David Mabunda announced on Wednesday. SANParks has also appointed a retired, decorated army major-general, Johan Jooste, to oversee the anti-poaching operations in the Kruger National Park, as part of its multi-pronged strategy to combat rhino poaching. “This strategy is to leverage on existing capacities and strategic alliances, while bringing much-needed thinking and innovation on existing gaps and loopholes,” Mabunda said. Mabunda commended a Kruger National Park ranger who, three weeks ago, alerted SANParks officials and the police to an offer of collusion from suspected poachers, helping to stage the sting operation that led to their successful arrest. “His honesty, commitment and diligence to the cause of protecting the rhino has not gone unnoticed; the organization will reward his good deed accordingly,” Mabunda said. South Africa has lost an unprecedented number of rhinos over the last five years, most which were killed in the Kruger National Park. Major-General Jooste, 60, has vast experience in military intelligence and border protection, knowledge of modern technology use and integration, and some knowledge of conservation. Jooste said he was “not a Messiah, but a proven leader and a team player. I will do my best to bring acceptable results. This fight against poaching is not about an individual, and success depends on the collective collaboration and commitment from the men and women tasked with the responsibility of conserving our heritage.” Jooste’s appointment follows the deployment of a Seeker Seabird reconnaissance aircraft donated by the Ichikowits Family Foundation, as well as an Unmanned Aerial Vehicle (UAV) Seeker 2, loaned to SANParks by arms manufacturer Denel. The two aircraft will provide the much needed intelligence, especially at night, when most poaching incidents take place. “This will give added advantage to the ground troops and will hopefully act as a deterrent,” Mabunda said. Source: SANews.gov.zalast_img read more

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Tony Blair to Advise Silicon Valley Green-Tech VC Firm Khosla Ventures

first_imgTop Reasons to Go With Managed WordPress Hosting Tags:#People in Tech#web chris cameron 8 Best WordPress Hosting Solutions on the Market A Web Developer’s New Best Friend is the AI Wai…center_img Why Tech Companies Need Simpler Terms of Servic… Former British Prime Minister Tony Blair is joining Silicon Valley-based venture capital firm Khosla Ventures as a public policy advisor for the firm’s green-tech investments, according to a press release from the firm today. Founded by Vinod Khosla in 2004, Khosla Ventures is one of the leaders in environmental tech investing – a field of entrepreneurship Blair says is paramount to turning around the energy and climate crisis facing the world today.According to the release, Blair and his team “will leverage his advocacy for environmental issues and his global relationships to help Khosla’s broad portfolio of clean technology companies maximize their effectiveness in achieving their environmental goals.” During his time as prime minister, Blair led efforts to address the climate and energy crisis. Today he heads the Breaking the Climate Deadlock initiative, which is aimed at uniting world leaders for global climate policy. “Solving the climate crisis is more than just a political agenda item – it’s an urgent priority that requires innovation, creativity, and ambition,” said Blair. “I share a clear vision with Vinod, one of the earliest leaders in cleantech investment, that entrepreneurs in Silicon Valley and beyond will have a tremendous impact on our environmental future.”Based on his continuing work with international climate-control policies, it is likely that Blair will offer Khosla Ventures and its portfolio of green-tech companies both policy advice and connections to government officials who support these efforts. Blair will also likely provide the firm with advice on new investments, though there was no mention whether he will provide any funding himself as an angel.The partnership was announced before a private audience of portfolio companies and limited parters and other Khosla funders, including Bill Gates. Aside from its green-tech investments, Khosla Ventures has helped fund IT startups like Square, Hunch and Xobni.This announcement is great news for green-tech companies, which saw a significant dip in venture funding last year. Khosla’s partnership with Blair is a large step forward in their dedication to environmental tech investments – a field in which they are clearly determined to become the hands-down leader. Overall, other VC funding figures have been lackluster so far in 2010, but Khosla’s clean tech initiatives could help these numbers rebound as the year continues.Photos courtesy of The World Economic Forum on Flickr. Related Posts last_img read more

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Meralco eyes q’final bonus

first_imgBrace for potentially devastating typhoon approaching PH – NDRRMC And with the top four seeds still up for grabs, Bolts head coach Norman Black knows they’ll have to make the most of having their fate still in their hands.“I think you need at least eight wins to get the twice-to-beat advantage and we still have two games left and there’s a lot of teams fighting so this is the time of the conference when you need to win games,” said Black.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutMeralco owns a 7-2 record and will look to book that eighth win today in the duel against the Batang Pier, who are already out of the quarterfinals picture after slipping to a 3-7 record.“That’s really the goal this conference, to try to get that twice-to-beat advantage because that’s the incentive,” said Black, whose team sits at second spot behind Ginebra’s 8-2 record. LATEST STORIES Fire hits houses in Mandaluyong City MOST READ Meralco looks to punch its twice-to-beat ticket in the quarterfinals of the PBA Governors’ Cup as early as possible and hopes it can do so Friday against GlobalPort at Mall of Asia Arena.ADVERTISEMENT So, Ding go through tiebreaks BSP sees higher prices in November, but expects stronger peso, low rice costs to put up fight Frontrow holds fun run to raise funds for young cancer patients  Trending Articles PLAY LIST 00:50Trending Articles00:50Trending Articles00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Gamescenter_img Read Next View comments LOOK: Loisa Andalio, Ronnie Alonte unwind in Amanpulo for 3rd anniversary The top four teams of the tournament at the end of the elimination round will have twice-to-beat boosts in the quarterfinals. And although the Bolts have a lofty slot, defending champion San Miguel Beer, NLEX, and TNT all have 7-3 records, and can bump off Meralco from its perch.In a conference where a win or a loss can drop a team several spots down the standings, Black knows he has his work cut out for him against GlobalPort, which is hoping to exit the season with a win.In the other matchup, Star will look to bounce back after losing to TNT, 104-99, on Sept. 17 as the 5-4 Hotshots look to add another loss to Kia’s 0-10 slate.ADVERTISEMENT Nonong Araneta re-elected as PFF president Kammuri turning to super typhoon less likely but possible — Pagasa E.T. returns to earth, reunites with grown-up Elliott in new ad  Don’t miss out on the latest news and information. last_img read more

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Dimitrov wins ATP Finals, targets Grand Slam next

first_imgQC cops nab robbery gang leader, cohort That was not the only record Dimitrov set. After winning all five of his matches at the O2 Arena, he became the first player to win the elite tournament on debut since 1998, when Alex Corretja of Spain triumphed in Hanover.“I was a little bit tired,” said Dimitrov, who beat Goffin for the loss of just two games when they met on Wednesday. “I had to play a few matches obviously back-to-back against solid opponents. I knew that David is going to try something new. He had to be aggressive in order so he doesn’t let me play my game.”Goffin’s adjustments paid off early as he broke Dimitrov’s first two service games either side of losing his own, before settling down to control the opener.However, Dimitrov fought his way back. He leveled in the eighth game before breaking once more in the 12th to snatch the set, despite Goffin hitting eight more winners.Dimitrov’s confidence carried into the second set, where he brought up the first break point in the sixth game, only for Goffin to produce a stunning cross-court backhand winner to save it. The momentum back with him, Goffin broke the following game for a 4-3 lead and calmly closed out the set.ADVERTISEMENT Filipino athletes get grand send-off ahead of SEA Games PLAY LIST 01:27Filipino athletes get grand send-off ahead of SEA Games00:50Trending Articles00:59Sports venues to be ready in time for SEA Games01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games Tams rip Eagles, force do-or-die Read Next Grigor Dimitrov of Bulgaria lifts the trophy after beating David Goffin of Belgium in their ATP World Tour Finals singles final tennis match at the O2 Arena in London pn Sunday, November 19, 2017. (AP Photo/Tim Ireland)LONDON — Grigor Dimitrov’s talent took him to the brink of his biggest career win, but he needed more than that to get over the line.ADVERTISEMENT View comments Stronger peso trims PH debt value to P7.9 trillion Typhoon Kammuri accelerates, gains strength en route to PH LATEST STORIES CPP denies ‘Ka Diego’ arrest caused ‘mass panic’ among S. Tagalog NPA Japan ex-PM Nakasone who boosted ties with US dies at 101 MOST READ Kammuri turning to super typhoon less likely but possible — Pagasa Kris Aquino ‘pretty chill about becoming irrelevant’ The sixth-seeded Bulgarian claimed the title at the season-ending ATP Finals on Sunday, prevailing on his fifth match point to beat David Goffin 7-5, 4-6, 6-3 in the final.“I felt I had a good mental toughness throughout the whole year,” Dimitrov said. “So when my body’s allowing me to do this kind of preparation, I feel I already have an advantage over any other player. And right now those are the moments that I rise up to.”FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutoutIt was not the Roger Federer-Rafael Nadal matchup many fans had hoped for, but they were left satisfied as the two 26-year-olds delivered the longest final since the tournament returned to a three-set format in 2008.Dimitrov won in 2 hours, 30 minutes, 15 seconds, adding 11 minutes to the mark set by Federer and Jo-Wilfried Tsonga in 2011. Having become the sixth player to beat Nadal and Federer at the same tournament — the latter from a set down in the semifinals — Goffin had every reason to be confident after drawing level. But he wasted four break points in the opening game and they would turn out to be his only chances in the decider.“I think after this week I’m a better player mentally,” said Goffin, who ends the season at a career-high No. 7 ranking. “I proved to myself that I can do it.”Dimitrov was more clinical, striking in the sixth game to take control of the third set. However, the Bulgarian has had problems closing matches out this season — losing three times after holding match points — and had cause for concern when Goffin saved his first three to hold from 0-40 down at 2-5.Dimitrov served his way to 40-15 but saw another chance drift away, before Goffin finally netted a backhand volley to end the match.“I was a little bit tired in the third,” Goffin said. “It’s the only game maybe I didn’t serve well. I didn’t put a lot of first serves in that game … He was really solid.”Dimitrov claimed his first Masters title in Cincinnati in August, and having risen to a career-high No. 3-ranking with victory in London, his next target is a Grand Slam.“I don’t want to get too hyped up because I’ve done well, now I’m No. 3 in the world,” Dimitrov said. “Of course, one of my main goals is to win a Grand Slam tournament. This has always been, again, a dream of mine.”        /kga Don’t miss out on the latest news and information. Brace for potentially devastating typhoon approaching PH – NDRRMClast_img read more

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Dellavedova ‘lucky’ to have played with LeBron, Giannis

first_imgView comments LATEST STORIES Matthew Dellavedova. Photo by Randolph B. Leongson/ INQUIRER.netFor someone who wasn’t supposed to make it, Matthew Dellavedova should be considered as a picture of success.With a championship ring on his finger and a shoe line to boot, he has gone a long way since being undrafted in the 2013 NBA Draft.ADVERTISEMENT Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ Lanete working on consistency after solid first game back for Bolts Trending Articles PLAY LIST 00:50Trending Articles02:29Giannis Antetokounmpo powers Bucks in bounce back win over Celtics00:50Trending Articles02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Lacson: SEA Games fund put in foundation like ‘Napoles case’ Don’t miss out on the latest news and information. Church, environmentalists ask DENR to revoke ECC of Quezon province coal plant FEU Auditorium’s 70th year celebrated with FEU Theater Guild’s ‘The Dreamweavers’center_img Trump strips away truth with hunky topless photo tweet With the Bucks, the 6-foot-4 point guard saw first hand the transformation of Antetokounmpo from an intriguing Greek prospect to one of the league’s top players tiday.“Giannis is a really special guy. He just won the Most Improved Player and I think he could win that again next year because he doesn’t have the ceiling. I’m looking forward to his future,” he said.Dellavedova also hopes he could see more  Australian players roam the NBA.“It’s a lot of fun having a lot of Aussies in the NBA,” he said referring to the Australian delegation that includes Patty Mills, Andrew Bogut, Aron Baynes, Joe Ingles, and Dante Exum.“I think with Luc Longley, Andrew Gaze, Shane Heal, those Australian legends, that opened the floodgates for the rest of us to come to the NBA. Hopefully, we’ll have more to come.”Sports Related Videospowered by AdSparcRead Next MOST READ National Coffee Research Development and Extension Center brews the 2nd National Coffee Education Congress “I’m really lucky to have gotten a chance to play with them,” he said Friday during the official launch of the Peak Store at Robinson’s Place Manila in Ermita.The Australian playmaker spent his first three years in the league playing back up for Kyrie Irving in Cleveland and also saw up-close how hard James works on and off the court.“I was lucky enough to play with Lebron for two years and there’s a reason why he’s the best player in the world. He just works so hard every day, watching game tape, and I really learned a lot from him,” he said.The Cavaliers went to two Finals during his stay there, winning the 2016 NBA Championship after battling back from a 1-3 deficit against the famed Golden State Warriors.That experience, Dellavedova shared, truly helped him a lot when he decided to make the jump last year, leaving Cleveland to test his luck in Milwaukee.ADVERTISEMENT Hotel says PH coach apologized for ‘kikiam for breakfast’ claim Robredo should’ve resigned as drug czar after lack of trust issue – Panelo Dellavedova also had the golden opportunity to play alongside two once-in-a-generation players in LeBron James and Giannis [email protected] compares his time playing with @KingJames and @Giannis_An34 pic.twitter.com/lCgobm9pA7FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool stars— Randolph B. Leongson (@RLeongsonINQ) July 21, 2017last_img read more

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